Microglial Activation parallels System Degeneration in progressive Supranuclear palsy and Corticobasal Degeneration
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چکیده
منابع مشابه
Procerus sign in progressive supranuclear palsy and corticobasal degeneration.
The procerus sign was described by Romanoand Colosimo (1) in two patients with progressive supranuclear palsy (PSP), being defined as the appearance of vertical wrinkles in the glabellar region and the bridge of the nose due to dystonic contractions of the procerus muscle, associated with a combination of reduced blinking, spasticity, lid retraction, and gaze palsy. This occurs because the proc...
متن کاملProgressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options
OPINION STATEMENT There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms. The use of most pharmacological treatment options are based on experience in other disorders or from non-randomized historical controls, case ...
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Pathological tau proteins that constitute the basic matrix of neuronal inclusions observed in numerous neurodegenerative disorders are disease specific. This is mainly the consequence of the aggregation of specific sets of tau isoforms according to the diseases, i.e., six isoforms in Alzheimer's disease (AD) and exclusively the three tau isoforms lacking the corresponding sequence of exon 10 (E...
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Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variants. Microglial and glial cytoplasmic inclusion (GCI) burdens were determined wi...
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Neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits. Comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. The six tau isoforms found in human brain contain either three (3R) or four microtubule-binding domains (4R). In Alzheimer's disea...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2001
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/60.6.647